Penny: I'm so sorry. I know that that's useless to you right now. But I am. He saved all those people. And it was my job... to save him. And I failed. And now... He's gonna die... Because I was not a good enough doctor... to keep him alive.
Meredith: Yeah, you're right. You did fail. You weren't good enough. But do you know what tomorrow is? It's Friday. There's gonna be more patients who come in who need you to save them... someone's mother, someone's kid, someone's husband. They need you to save them because they can't save themselves. So learn from this, better yourself, and you will be better for next time.
Penny: What if I'm not?
Meredith: You will be.
Penny: How can you know that?
Meredith: Because he was your one. Every patient you treat, you're going to see my husband's face and remember that he was the one that died on your watch. He will haunt you. The hard ones always do. And it only takes that one. But that one will make you work harder, and they make you better. Or they make you quit, and you don't get to waste what would have been the rest of my husband's life being a quitter. So get back inside because you're not saving any lives out here.